The IACUC is a standing committee and charged under the Animal Welfare Act with representing “....society's concerns regarding the welfare of animal subjects ...” The Committee oversees the University’s animal care and use program and is responsible for reviewing all animal care applications using vertebrate animals, ensuring compliance with federal animal welfare regulations, inspecting animal facilities and investigator laboratories, and investigating animal concerns.
The Animal Care and Use Protocol describes, in detail, how an investigator will utilize animals in their proposed research. This animal care and use protocol is submitted through Research Compliance System (RCS) online system.
An Animal Care and Use protocol should be submitted to the IACUC for all research that involves the use of live vertebrate animals for testing, instructional and research purposes.
When protocol submission is received, it will undergo pre-review process. If additional details are needed based on pre-review feedback, the Compliance Administrator may contact investigator to request revisions. Once revisions is received and protocol added on the agenda for IACUC review, feedback from the meeting is sent back to the investigator (usually takes 5-7 business days following a meeting). Most protocol revisions would at least require minimal time, however other protocols could require additional time, for IACUC reviewers to verify that responses to the IACUC questions have been adequately clarified. All requested modifications must be addressed before final protocol approval is granted. No animals may be ordered or research procedures conducted prior to the receipt of written IACUC approval.
Refer to the “Meeting & Deadline Calendar” for submission deadlines.
On average, IACUC approval is received within 3-4 weeks of protocol submission. Approval times vary depending on the completeness of the protocol and the efficiency of the investigator in addressing the committee's questions regarding the submitted protocol. Therefore, it is recommended that investigator plans for 4-6 weeks to obtain IACUC protocol approval.
IACUCs must confirm that:
For further guidance, the IACUC should refer to the U.S. Government Principles.
Yes. Pilot studies may be appropriate to determine the technical feasibility of larger studies or to make initial assessments of the effect of procedures on animals (Guide pages 26, 28). Whether proposed by investigators or required by the IACUC, pilot studies require review and approval by the IACUC in accordance with the PHS Policy.
NO. IACUCs do not have authority to administratively extend approval beyond three years. When IACUC approval expires the protocol lacks valid approval. Continuation of animal activities in the absence of valid approval is a serious and reportable violation of PHS Policy (See NOT-OD-05-034) [A11], and may jeopardize both investigator and university funding. All activities involving the use of animals must stop immediately. Animals will go on the ARF Holding Protocol for only routine husbandry (no research manipulations) and federal funds may not be used to pay for housing per diems during this time.